The SENSUS™ Pain Management System:
The SENSUS Pain Management Device is a non-invasive transcutaneous electrical nerve stimulator intended to be used in the symptomatic relief and management of chronic intractable pain. SENSUS employs the same sophisticated nerve stimulation technology as the Company's NC-stat® DPNCheck™ device, and includes advanced features that NeuroMetrix believes may address the technical and clinical limitations of existing nerve stimulators. The device also includes technology to maximize patient compliance, which is one of the fundamental challenges with pain therapy.
How Does SENSUS Work?
The patient snaps an electrode into the stimulator and then secures the stimulator around the upper calf. Prior to first use, and from time to time, the device is personalized through a quick and straightforward procedure. Pain relief is initiated by simply pressing a button. The physiological principle is that excitation of normal nerves reduces transmission of pain signals to the brain. This may occur through inhibition of neurons in the spinal cord that transmit pain signals further up in the central nervous system. There is also evidence that supraspinal structures activate pain suppression pathways through release of opiod peptides1 and other neuromodulatory agents.2
Transcutaneous electrical nerve stimulation has been shown to provide pain relief for patients with diabetes.
A number of recent systematic literature reviews and meta-analyses concluded that transcutaneous electrical nerve stimulation may be an effective and safe treatment for painful diabetic neuropathy.3-6
1. Leonard G, Goffaux P, Marchand S. Deciphering the role of endogenous opioids in highfrequency TENS using low and high doses of naloxone. Pain. Oct 2010;151(1):215-219.
2. Johnson MI, Bjordal JM. Transcutaneous electrical nerve stimulation for the management of painful condition: focus on neuropathic pain. Expert Rev Neurother. May 2011;11(5):735-753.
3. Jin DM, Xu Y, Geng DF, Yan TB. Effect of transcutaneous electrical nerve stimulation on symptomatic diabetic peripheral neuropathy: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. Jul 2010;89(1):10-15.
4. Cruccu G, Aziz TZ, Garcia-Larrea L, et al. EFNS guidelines on neurostimulation therapy for neuropathic pain. Eur J Neurol. Sep 2007;14(9):952-970.
5. Pieber K, Herceg M, Paternostro-Sluga T. Electrotherapy for the treatment of painful diabetic peripheral neuropathy: a review. J Rehabil Med. Apr 2010;42(4):289-295.
6. Dubinsky RM, Miyasaki J. Assessment: efficacy of transcutaneous electric nerve stimulation in the treatment of pain in neurologic disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. Jan 12 2010;74(2):173-176.